Nebido 1000 mg 4 ml solution for injection Patient Information Leaflet PIL emc

Your doctor will inject Nebido (1 ampoule / vial) very slowly into a muscle. This is enough to maintain sufficient testosterone levels without leading to a build-up of testosterone in the blood. There are no studies undertaken to demonstrate the efficacy and safety of this medicinal product in patients with renal or hepatic impairment.

• Your doctor will measure your blood testosterone levels before starting treatment and during the early stages of treatment.
• Pulmonary microembolism of oily solutions can in rare cases lead to signs and symptoms such as cough, dyspnoea, malaise, hyperhidrosis, chest pain, dizziness, paraesthesia, or syncope.
• The active substance is testosterone undecanoate 250 mg/ml (corresponding to 157.9 mg testosterone).
• Care should be taken to inject Nebido deeply into the gluteal muscle following the usual precautions for intramuscular administration.

how to store nebido

Following intramuscular administration of thisdepot formulation the release rate is characterised by a half life of 90±40 days. Each ampoule / vial with 4 ml solution for injection contains 1000 mg testosterone undecanoate. Maintaining your Testosterone Undecanoate levels during treatment The injection interval should always be within the recommended range of 10 to 14 weeks. Testosterone has been found to be non-mutagenic in vitro using the reverse mutation model (Ames test) or hamster ovary cells. A relationship between androgen treatment and certain cancers has been found in studies on laboratory animals.

Testosterone undecanoate

Measurements should be performed at the end of an injection interval and clinical symptoms considered. These serum levels should be within the lower third of the normal range. Serum levels below normal range would indicate the need for a shorter injection interval. In case of high serum levels an extension of the injection interval may be considered. As with all oily solutions, Nebido must be injected strictly intramuscularly and very slowly (over two minutes). Pulmonary microembolism of oily solutions can in rare cases lead to signs and symptoms such as cough, dyspnoea, malaise, hyperhidrosis, chest pain, dizziness, paraesthesia, or syncope.

With this loading dose, sufficient steady state testosterone levels may be achieved more rapidly. Treatment with high doses of testosterone preparations commonly stops or reduces sperm production, although this returns to normal after treatment ceases. Testosterone replacement therapy of poorly functioning testicles (hypogonadism) can in rare cases cause persistent, painful erections (priapism). High-dosed or long-term administration of testosterone occasionally increases the occurrences of water retention and oedema (swelling due to fluid retention). Depending on serum testosterone levels and clinical symptoms, the first injection interval may be reduced to a minimum of 6 weeks as compared to the recommended range of 10 to 14 weeks for maintenance. With this loading dose, sufficient steady state testosterone levels may be achieved more rapidly.

Nebido is an intramuscularly administered depot preparation of testosterone undecanoate and thus circumvents the first-pass effect. Following intramuscular injection of testosterone undecanoate as an oily solution, the compound is gradually released from the depot and is almost completely cleaved https://mendenarena.de/igf1-lr3-1mg-peptide-sciences-how-to-buy/ by serum esterases into testosterone and undecanoic acid. An increase in serum levels of testosterone above basal values may be seen one day after administration. The treatment did not exhibit any adverse side effects on the prostate gland, including prostate-specific antigen. Following intramuscular injection of testosterone undecanoate as an oily solution, the compound is gradually released from the depot and is almost completely cleaved by serum esterases into testosterone and undecanoic acid. An increase in serum levels of testosterone above basal values may be seen one day after administration.